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A 17-year-old boy presented with recurrent headache for several weeks and sudden vision loss on the left eye to light perception. On slit lamp examination partial aniridia with transillumination was identified (Fig 1A). Ophthalmoscopy and angiography of the left eye revealed a central retinal artery occlusion (Fig 1B, D). Computed tomography of the cardiovascular and cerebrovascular system discovered ectasia of all major arterial vessels, including carotid and cerebral arteries (Fig 1C). Genetic analysis revealed a missense mutation of the ACTA2 gene, encoding for a smooth muscle isoform of α-actin.

在年龄相关性黄斑变性治疗对照试验 (Comparison of Age-related Macular Degeneration Treatment Trials [CATT]) 第2年结果分析中, Sharma (p. 865) 等对视力 (visual acuity [VA]) 和眼底照片 (fundus photography [FP]) 、荧光素血管造影 (fluorescein angiography [FA]) 、光学相干断层扫描 (optical coherence tomography [OCT]) 等形态学特征的相关性进行了描述。研究者发现这项前瞻性随机研究中, 第1年随访中观察到VA和形态学特征的相关性在第2年随访中得到保持或增强。经过2年玻璃体腔注射治疗后, 视力最差者见于具备以下特征患眼:OCT显示残留中心凹视网膜层间积液、视网膜异常变薄、增厚的视网膜下组织复合体、或FP/FA示中心凹下地图样萎缩或瘢痕形成。反之, 中心凹视网膜下积液与较好VA相关。在1185名CATT受试者中, 993 (84%) 人基线时OCT见积液并完成了2年随访。

The authors of “Vasodilators, Blood Pressure-Lowering Medications, and Age-Related Macular Degeneration: The Beaver Dam Eye Study” (Ophthalmology 2014;121:1604-11) wish to make the following correction to their paper:

En un análisis del segundo año de la Comparación de Estudios de Tratamiento de Degeneración Macular Relacionada con la Edad (CATT), Sharma y otros (p. 865) describieron la asociación entre la agudeza visual (VA) y las características morfológicas de la fotografía del fondo de ojo (FP), la angiografía con fluoresceína (FA) y la tomografía de coherencia óptica (OCT). Encontraron que la asociación entre la VA y las características morfológicas identificadas durante el primer año de este estudio prospectivo, aleatorio se mantuvieron o se fortalecieron durante el segundo año.


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