Aryl Hydrocarbon Receptor-Interacting Protein-Like 1 in Cancer-Associated Retinopathy

Paraneoplastic syndromes constitute symptoms from organs distant from a malignant neoplasm present in the body, and are in many cases mediated by immune cross-reactivity between the neoplasm and normal host tissue. Cancer-associated retinopathies (CAR) are rare retinal disorders associated with autoantibodies directed to various retinal antigens. The immune response initially arises to suppress a tumor growth, ultimately resulting in rapid, bilateral, and painless loss of vision.1 If a subsequent clinical investigation reveals an underlying malignancy, the retinal damage is categorized as a paraneoplastic syndrome.