Clinical Characterization of -Related Pediatric High Myopia

Nonsyndromic myopia is increasing in frequency throughout the world, particularly high myopia (≥−6.0 diopters [D]), which is more associated with complications such as chorioretinal atrophy and retinal detachment.1 Although high myopia is sometimes clearly familial, only a limited number of genes have been associated with monogenic nonsyndromic myopia to date. Those associated with autosomal dominant nonsyndromic high myopia include zinc finger protein 644 (Online Mendelian Inheritance in Man [OMIM] *614159, ZNF644), SCO2 cytochrome c oxidase assembly protein (OMIM *604272, SCO2), solute carrier family 39 zinc carrier member 5 (OMIM *608730, SLC39A5), procollagen proline 2-oxoglutarate-4-dioxygenase alpha subunit isoform 2 (OMIM *600608, P4HA2), and coiled coil containing domain 111 (OMIM *615421, CCDC111).