Watanabe et al (p. 2103) investigated the effect of corneal guttae severity on the quality of vision in patients with mild Fuchs’ corneal dystrophy. They found that corneal guttae—even without edema seen on slit-lamp examination—have a negative impact on patients’ quality of vision, and that intraocular forward light scatter caused by the guttae may result in visual disturbances. This cross-sectional study included 23 eyes of 14 patients who had Fuchs’ dystrophy but no evident edema. The researchers evaluated the area ratio of the guttae and correlated that with corrected distance visual acuity (CDVA), letter contrast sensitivity (LCS), and intraocular straylight.


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