A nodular tumor had grown from the palpebral conjunctiva over the lower lid margin of the left eye in a 62-year-old man during 5 months (Fig 1A). Histopathologically, a smaller portion around the lid margin resembled squamous cell carcinoma (Fig 1B, right). It merged into a major undifferentiated portion replacing the palpebral conjunctiva, with high mitotic activity (Fig 1B, left), focal glandular differentiation including mucin production (Fig 1C, Acian blue positive), and immunopositivity for cytokeratin-7 (Fig 1D) and carcinoembryonic antigen (CEA).

A 56-year-old man presented with 20/400 vision in the right eye. Ophthalmoscopy revealed deep retinal punctate mottling extending temporally (Fig 1, left). En face optical coherence tomography (OCT) demonstrated corresponding hyperreflective dots at the level of the outer retina (Fig 1, top right). Serologic testing confirmed a diagnosis of active syphilitic chorioretinitis. The patient received intravenous penicillin for 7 days. On 1 week follow-up vision had improved to 20/30 with en face outer retinal OCT revealing disappearance of the hyperreflective dots (Fig 1, bottom right).

The authors of “A Multicenter Prospective Cohort Study of Quality of Life and Economic Outcomes after Cataract Surgery in Vietnam” (Ophthalmology 2014;121:2138–46) would like to make the following correction to their article abstract.

Matoba et al (p. 451) observed a dendritiform keratopathy associated with topical ophthalmic exposure to the preservative polyquaternium-1 (PQ-1). For this case series, the researchers reviewed the records of 16 patients who were exposed to PQ-1 either via their use of contact lens disinfecting solutions (n = 13) or artificial tear products (n = 3). All of the patients experienced resolution of the dendritiform lesions within 2 to 6 weeks after their exposure to PQ-1 was eliminated. The authors emphasized the importance of differential diagnosis, as 10 of the 16 patients were initially treated for herpes simplex virus keratitis or acanthamoeba keratitis.

In their recent article, Watanabe et al1 explored relationships between corneal guttae and visual function in eyes with “mild” Fuchs' endothelial corneal dystrophy (FECD).1 They concluded that guttae affect quality of vision (QOV), and that “early endothelial keratoplasty for patients with mild FECD without severe edema should be considered to remove corneal guttae that affect the QOV parameters.”

Over the last decade, nonsteroidal anti-inflammatory drugs (NSAIDs) have been used increasingly in the setting of cataract surgery. Despite overwhelming acceptance of this practice, there is a paucity of data that clearly demonstrates the effectiveness of NSAIDs in improving long-term visual outcomes. According to a survey in 2012 by the American Society of Cataract and Refractive Surgery, 90% of its membership routinely prescribes an NSAID in addition to, but not as a replacement for, a corticosteroid during cataract surgery at a cost of nearly $200 per brand prescription and amounting to an annual societal cost approximating $540 million.